The Extract of Rosa roxburghii Tratt Alleviates Pulmonary Fibrosis in Mice via Gut Microbiota‐Amino Acid Metabolism and JAK2/STAT3 Inhibition
Ting Zhou, Heting Zhou, Xinyue Zheng, Xiaomeng Wang, Tao Chen, Xingjie Li, Liqun Wang, Shouqian Li, Yongmei Xie, Lijun Peng, Wenya Yin · 2026
Read The Extract of Rosa roxburghii Tratt Alleviates Pulmonary Fibrosis in Mice via Gut Microbiota‐Amino Acid Metabolism and JAK2/STAT3 Inhibition by Ting Zhou, Heting Zhou, Xinyue Zheng, Xiaomeng Wang, Tao Chen, Xingjie Li, Liqun Wang, Shouqian Li, Yongmei Xie, Lijun Peng, Wenya Yin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13136511.txt.
Description
Scarred lungs stiffen until breathing fails, and a thorny fruit extract might slow the scarring. Ting Zhou and co-authors test in 2026 extracts of Rosa roxburghii, a plant rich in protective compounds, in mice with pulmonary fibrosis. The ethyl acetate extract carried the most active content and the strongest antioxidant punch, so it led the animal work.
Treated mice showed friendlier gut microbes, corrected amino acid chemistry centered on tryptophan, and quieter scarring signals in the lung: less cell-shape shifting toward scar tissue and a damped JAK2/STAT3 pathway. The authors frame the benefit as a gut-lung partnership worth clinical exploration.
Catalog record
| CREATOR | Ting Zhou, Heting Zhou, Xinyue Zheng, Xiaomeng Wang, Tao Chen, Xingjie Li, Liqun Wang, Shouqian Li, Yongmei Xie, Lijun Peng, Wenya Yin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |