Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma
Chunzhao Li, Peng Zhang, Xiaobin Zhao, Rui Feng, Na Xian, Gangxiong Huang, Wenju Jiang, Zhenhua Hu, Yang Zhang, Nan Ji · 2026
Read Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma by Chunzhao Li, Peng Zhang, Xiaobin Zhao, Rui Feng, Na Xian, Gangxiong Huang, Wenju Jiang, Zhenhua Hu, Yang Zhang, Nan Ji (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13135600.txt.
Description
Chunzhao Li and co-authors build a tracking system for cancer-fighting immune cells in a 2026 study. Engineered T cells, called CAR-T cells, are being tested against glioblastoma, a fierce brain tumor, by delivering them straight into the brain's fluid spaces. Once inside, though, no one could say exactly where the cells traveled or how long they stayed.
The team tagged the cells with tiny iron particles joined to a glowing dye, without hurting the cells' killing power. Two scan types then followed the tagged cells in mice with brain tumors: one gave sharp anatomical maps, the other a glow that scaled with cell counts. The paired scans revealed route-dependent patterns of where cells gathered near the tumor and how they spread through the body over time. The method gives drug developers a way to tune delivery before human trials.
Catalog record
| CREATOR | Chunzhao Li, Peng Zhang, Xiaobin Zhao, Rui Feng, Na Xian, Gangxiong Huang, Wenju Jiang, Zhenhua Hu, Yang Zhang, Nan Ji |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |