Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype
John L Robinson, Helen Cai, Nicholas J Loh, Omar Vazquez, Zahra Khodakaramimaghsoud, EunRan Suh, Vivianna M Van Deerlin, Paul A Yushkevich, Dawn Mechanic-Hamilton, Sharon X Xie, Daniel T Ohm, David A Wolk, David J Irwin, Jeffrey S Phillips, Edward B Lee · 2026
Read Idiotypic-susceptible Alzheimer’s disease: a clinically relevant, neurofibrillary tangle subtype by John L Robinson, Helen Cai, Nicholas J Loh, Omar Vazquez, Zahra Khodakaramimaghsoud, EunRan Suh, Vivianna M Van Deerlin, Paul A Yushkevich, Dawn Mechanic-Hamilton, Sharon X Xie, Daniel T Ohm, David A Wolk, David J Irwin, Jeffrey S Phillips, Edward B Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13135531.txt.
Description
John Robinson and co-authors define in a 2026 study a tangle subtype of Alzheimer's disease that favors primary brain areas. Tangles usually march from memory zones to association areas and last to primary zones. Burden in those last zones was little studied despite known spread variety.
Tangle density was stained and counted in eight brain zones across 144 high change cases. Diagnoses spanned late and early onset forms plus five look alike conditions. Cases were sorted by tangle ratios into four mutually exclusive subtypes. One subtype loads primary zones far past the usual pattern, named idiotypic susceptible by the team. Its clinical weight is weighed against the other three patterns in the paper.
Catalog record
| CREATOR | John L Robinson, Helen Cai, Nicholas J Loh, Omar Vazquez, Zahra Khodakaramimaghsoud, EunRan Suh, Vivianna M Van Deerlin, Paul A Yushkevich, Dawn Mechanic-Hamilton, Sharon X Xie, Daniel T Ohm, David A Wolk, David J Irwin, Jeffrey S Phillips, Edward B Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |