Serositis as possible manifestation in MDS/AML patients with complex karyotype and TP53 mutation: case series
Eleonora Gugole, Edoardo Tamellini, Sara Jance, Nicola Serafin, Pietro Antonini, Chiara Colato, Mauro Krampera, Isacco Ferrarini, Ilaria Tanasi · 2026
Read Serositis as possible manifestation in MDS/AML patients with complex karyotype and TP53 mutation: case series by Eleonora Gugole, Edoardo Tamellini, Sara Jance, Nicola Serafin, Pietro Antonini, Chiara Colato, Mauro Krampera, Isacco Ferrarini, Ilaria Tanasi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13135004.txt.
Description
Some blood cancers announce themselves through inflammation far from the marrow. Eleonora Gugole and co-authors describe four patients with myelodysplastic syndromes or acute myeloid leukemia whose chest and abdominal linings inflamed without any infection to blame. All four shared a grim genetic profile: a mutated TP53 gene and a scrambled, complex set of chromosomes.
Every patient's serositis settled with corticosteroid treatment. The authors propose the inflammation as a possible calling card of this genetic subtype, an immune misfire tied to the cancer's biology. Recognizing the pattern matters, because steroids, not antibiotics, are the answer. The series is small, and the authors present it as a signal worth watching in similar patients.
Catalog record
| CREATOR | Eleonora Gugole, Edoardo Tamellini, Sara Jance, Nicola Serafin, Pietro Antonini, Chiara Colato, Mauro Krampera, Isacco Ferrarini, Ilaria Tanasi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |