Design, synthesis, and biological evaluation of tyrcinnamine derivatives as bactericides
Lijie Zheng, Baoyue Wei, Ji Pang, Yichen Yang, Mingjie Zhang, Ke Ma, Shan Lu · 2026
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Description
Zheng and coauthors make new germ-killing compounds from a natural product. They built twelve new forms from a lead compound found in nature. The lead could halt germ growth but could not kill the germs. One new form, called 14, killed staph germs, even drug-proof strains.
Tests hint that form 14 breaks the germ cell wall and raises toxic oxygen forms. In wax moth larvae with drug-proof staph, form 14 curbed germ growth. The team sees form 14 as a strong base for new drugs. More tests must check safety and dose before use in people.
Catalog record
| CREATOR | Lijie Zheng, Baoyue Wei, Ji Pang, Yichen Yang, Mingjie Zhang, Ke Ma, Shan Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |