Emerging threat of Oropouche virus: Clinical features, experimental models, and virulence
Cigdem Alkan, Tetsuro Ikegami · 2026
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Description
Alkan and Ikegami review the emerging threat of Oropouche virus in a 2026 paper. The virus spreads mainly through biting midges and was long seen as a neglected tropical disease near the Amazon. Illness was usually a short fever, with rare brain inflammation.
A large recent outbreak spread into the Caribbean and brought a wider range of disease. Reported outcomes now include severe brain and nerve syndromes, lasting infection, fatal bleeding fever, fetal loss, and newborn defects. Animal models exist, but species differ in how they respond, which clouds mechanism studies. One viral protein blocks host cell transcription and is the main known virulence factor. The authors map major gaps in knowledge.
Catalog record
| CREATOR | Cigdem Alkan, Tetsuro Ikegami |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |