Successful Sequential and Additive Drug Challenge With Rapid Oral Desensitization in Rifampicin‐Induced Fever
Xin Yue Guo, Constantine Zois · 2026
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Description
Xin Yue Guo and Constantine Zois published a 2026 case report on a tuberculosis patient who developed fever from his own treatment. Side effects from first-line tuberculosis drugs are common and can force treatment to stop. The patient was a 63-year-old man with active tuberculosis of the lungs.
Doctors tested his drugs one by one, adding them back in sequence, and identified rifampicin as the cause of the fever. He then underwent rapid desensitization by mouth as an outpatient, taking growing doses until his body tolerated the drug. The approach worked, and he completed six months of treatment. Evidence for outpatient desensitization in mild delayed drug reactions is limited, so each successful case adds useful guidance.
Catalog record
| CREATOR | Xin Yue Guo, Constantine Zois |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |