Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers
Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin, Volker Dötsch, Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin · 2026
Read Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers by Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin, Volker Dötsch, Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13132549.txt.
Description
Xiaoyu Yu, Yuanjun He, Thedore Kamenecka, and Douglas Kojetin work toward a single account of how a pair of gene-switch proteins switches genes on when a drug-like molecule binds. The pair joins a member of the NR4A family with a partner called RXR. Standard theory says the binding simply helps recruit helper proteins that start gene reading.
Earlier work by the team found a stranger mechanism for one family member: the pair partly splits apart when the molecule binds. Here they test the same set of molecules on a related family member to see if the pattern holds. A unified mechanism would change how drugs aimed at these switches are designed. The study extends careful profiling from one pair to its close cousin.
Catalog record
| CREATOR | Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin, Volker Dötsch, Xiaoyu Yu, Yuanjun He, Thedore M Kamenecka, Douglas J Kojetin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |