The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats
Cajsa Aranäs, Christian E Edvardsson, Lindsay Zentveld, Daniel Vallöf, Sarah Witley, Maximilian Tufvesson-Alm, Olesya T Shevchouk, Jesper Vestlund, Elisabet Jerlhag · 2024
Read The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats by Cajsa Aranäs, Christian E Edvardsson, Lindsay Zentveld, Daniel Vallöf, Sarah Witley, Maximilian Tufvesson-Alm, Olesya T Shevchouk, Jesper Vestlund, Elisabet Jerlhag (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13130276.txt.
Description
Cajsa Aranäs and co-authors report a rat study from two thousand twenty-four on pairing two gut-hormone drugs to cut alcohol drinking. Alcohol use disorder has tangled brain roots, so combining drugs may help where single ones fall short. Two gut-brain peptides, amylin and GLP-1, each reduce drinking in rodents on their own.
The team paired activators of both receptors in rats of both sexes, in two drinking experiments. Adding the amylin drug to ongoing GLP-1 treatment lowered intake in males and females. Starting both at once cut intake at first, but tolerance then developed. Food intake and body weight fell consistently in both sexes. Inflammation markers did not change. The results support combined gut-hormone treatment as a lead for alcohol research.
Catalog record
| CREATOR | Cajsa Aranäs, Christian E Edvardsson, Lindsay Zentveld, Daniel Vallöf, Sarah Witley, Maximilian Tufvesson-Alm, Olesya T Shevchouk, Jesper Vestlund, Elisabet Jerlhag |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |