Transcriptional profiling of Pseudomonas aeruginosa biofilm life cycle stages reveals dispersal-specific biomarkers
Xavier Bertran Forga, Kathryn E. Fairfull-Smith, Jilong Qin, Makrina Totsika · 2026
Read Transcriptional profiling of Pseudomonas aeruginosa biofilm life cycle stages reveals dispersal-specific biomarkers by Xavier Bertran Forga, Kathryn E. Fairfull-Smith, Jilong Qin, Makrina Totsika (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13128677.txt.
Description
Xavier Bertran Forga and co-authors map which genes switch on at each stage of a bacterial biofilm's life: settling, maturing, and dispersing. Biofilms are surface-bound cell cities that resist drugs, so stage-specific markers could seed new treatments. Their 2026 study profiles a well-known biofilm bacterium grown in closed cultures.
Settling cells raised genes for a surface-sensing system. Maturing films raised genes for a glue sugar and for enzymes that tune a key signal. Dispersing cells raised a different set: genes for surface coatings, a fat-like signal, and enzymes that dissolve the film's own web. A master dispersal regulator rose more than sixfold. The authors offer these markers as targets for stage-aware anti-biofilm design.
Catalog record
| CREATOR | Xavier Bertran Forga, Kathryn E. Fairfull-Smith, Jilong Qin, Makrina Totsika |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |