Editorial: Regulatory science: addressing uncertainties in medicines development, evaluation and use
Liese Barbier, Carla Torre, Rosanne Janssens · 2026
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Description
Liese Barbier, Carla Torre, and Rosanne Janssens open a journal collection on uncertainty in medicines regulation, in this 2026 editorial. The European Medicines Agency has made handling uncertainty a stated priority. Every drug decision, from lab to clinic, rests on incomplete knowledge, yet there is no shared, structured way to name, weigh, and talk about what is unknown.
The editors trace how uncertainty flows downstream: gaps in trial evidence shape benefit-risk calls, then reimbursement choices, then bedside decisions. Developers, regulators, clinicians, patients, and health technology assessors all have a stake in doing this better. The collection they introduce seeks methods to spot, measure, reduce, and communicate uncertainty across the whole life of a medicine. The piece frames the problem and invites the research that follows in the issue.
Catalog record
| CREATOR | Liese Barbier, Carla Torre, Rosanne Janssens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |