Not all Group B Streptococci are alike: macrophage responses reveal inflammatory and immune-evasive strains
Larisa Janžič, Lucija Sršen, Sara Petrin, Alojz Ihan, Andreja Nataša Kopitar · 2026
Read Not all Group B Streptococci are alike: macrophage responses reveal inflammatory and immune-evasive strains by Larisa Janžič, Lucija Sršen, Sara Petrin, Alojz Ihan, Andreja Nataša Kopitar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13128655.txt.
Description
Larisa Janžič and four co-authors show that strains of Group B Streptococcus differ a lot in how they reset macrophages. The germ is still a top cause of sepsis and meningitis in newborns, in spite of steps to block it. How bad the disease gets shifts with the traits of each strain. Macrophages are key first guards. Yet how they react to each strain was poorly mapped.
Human THP-1 macrophages are dosed with 12 full mapped strains from real cases. The strains span types by coat, types by gene chain, and ways the disease shows. The team tracks cell signals, a key swelling switch, and gene use at early and late times. Reactions prove set by strain and shift over time. Coat type Ia and Ib strains fire the swelling switch fast. They free key swelling signals early. Other strains lean the other way. They dodge immune attack.
Catalog record
| CREATOR | Larisa Janžič, Lucija Sršen, Sara Petrin, Alojz Ihan, Andreja Nataša Kopitar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |