The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry
Naoki Suzuki, Ryusuke Yoshimi, Hiroki Mizuno, Chiharu Hidekawa, Natsuki Sakurai, Yuji Yoshioka, Daiga Kishimoto, Kaoru Takase-Minegishi, Shigeru Ohno, Nobuyuki Yajima, Ken-ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Toshimasa Shimizu, Ayuko Takatani, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima · 2026
Read The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry by Naoki Suzuki, Ryusuke Yoshimi, Hiroki Mizuno, Chiharu Hidekawa, Natsuki Sakurai, Yuji Yoshioka, Daiga Kishimoto, Kaoru Takase-Minegishi, Shigeru Ohno, Nobuyuki Yajima, Ken-ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Toshimasa Shimizu, Ayuko Takatani, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13128556.txt.
Description
Fat tissue releases signals that can stir the immune system. Naoki Suzuki and co-authors ask whether obesity raises relapse risk in lupus. They use LUNA, a nationwide Japanese registry for the disease. Patients with a body mass index of at least 18.5 were split into obese and normal-weight groups. The cutoff for obesity was 25. The team compared one-year relapse rates after registration. Relapse meant a rise in steroid dose during follow-up.
The analysis adjusted for age, sex, disease duration, activity, damage, and steroid history. Education and blood sugar markers were included too. The study tests whether weight management belongs in relapse prevention. Full results follow in the paper.
Catalog record
| CREATOR | Naoki Suzuki, Ryusuke Yoshimi, Hiroki Mizuno, Chiharu Hidekawa, Natsuki Sakurai, Yuji Yoshioka, Daiga Kishimoto, Kaoru Takase-Minegishi, Shigeru Ohno, Nobuyuki Yajima, Ken-ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Toshimasa Shimizu, Ayuko Takatani, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |