Identification and validation of druggable targets for cataract using mendelian randomization: functional insights from multi-omics and an oxidative stress model
Min Lin, Jie Zeng · 2026
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Description
Min Lin and Jie Zeng hunt for drug targets against cataract in a 2026 study. Cataract clouds the eye's lens and is a top cause of blindness, yet drugs to prevent it are lacking. Genes whose activity can be tuned by drugs offer a place to start. The team mined genetic and protein data to find genes that causally raise cataract risk.
They screened over 2,500 drug-linked genes with two kinds of genetic instruments. Thirty-five genes showed at the expression level and thirty-one at the protein level. Three genes, among them DKK3 and GSTM1, appeared in both lists. Wider scans suggested no major side effects from targeting them. Docking tests favored GSTM1 as the most promising target. Lens cells stressed with peroxide then tested how the key genes behave under damage.
Catalog record
| CREATOR | Min Lin, Jie Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |