Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism
Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo, Biyi Xu, Junke Mou, Mengyang Wang, Qishuo Gu, Qianhui Sun, Ying Lv, Xingtao Huang, Ming Zeng, Boling Yi, Xiaolin Liu, Xiaoxuan Bai, Cheng Fang, Ji Li, Bo Yu, Haibo Jia · 2026
Read Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism by Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo, Biyi Xu, Junke Mou, Mengyang Wang, Qishuo Gu, Qianhui Sun, Ying Lv, Xingtao Huang, Ming Zeng, Boling Yi, Xiaolin Liu, Xiaoxuan Bai, Cheng Fang, Ji Li, Bo Yu, Haibo Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13126339.txt.
Description
Tiny bubbles shed by cells can carry healing cargo through the blood. Xing Luo and co-authors test vesicles from vessel-lining progenitor cells against atherosclerosis. Cells raised in low oxygen shed richer vesicles than normal ones. In mice prone to artery disease, normal vesicles already slowed plaque growth. The low-oxygen vesicles did more: smaller plaques, more collagen, less fat, and calmer inflammation. Protein analysis pointed to ferroptosis, an iron-driven cell death, as the target.
One cargo protein, ASS1, proved central. Removing it erased the benefit, and adding it back restored protection. The chain runs through arginine supply to antioxidant defenses. The authors propose the vesicles as a cell-free therapy.
Catalog record
| CREATOR | Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo, Biyi Xu, Junke Mou, Mengyang Wang, Qishuo Gu, Qianhui Sun, Ying Lv, Xingtao Huang, Ming Zeng, Boling Yi, Xiaolin Liu, Xiaoxuan Bai, Cheng Fang, Ji Li, Bo Yu, Haibo Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |