Targeting the renin-angiotensin system in sepsis-associated AKI: from pathophysiology to precision medicine
Yuxin Dong, Lei Xia, Songtao Shou · 2026
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Description
A peer-reviewed research article from Europe PMC (2026). Sepsis-associated acute kidney injury (SA-AKI) is a common and life-threatening complication of sepsis. Increasing evidence suggests that dysregulation of the renin-angiotensin-aldosterone system (RAAS) is involved in its pathogenesis, but the direction of this dysregulation is not uniform. In some patients and experimental settings, elevated renin and angiotensin I levels are accompanied by an inadequate rise in circulating angiotensin II (Ang II), suggesting impaired effective Ang II generation and relative Ang II deficiency.
Catalog record
| CREATOR | Yuxin Dong, Lei Xia, Songtao Shou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |