Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected (“hub”), and leader beta-cells
Luis Fernando Delgadillo-Silva, Giada Ostinelli, Audrey Provencher-Girard, Shadai Salazar, Rana Melhem, Guy A. Rutter · 2026
Read Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected (“hub”), and leader beta-cells by Luis Fernando Delgadillo-Silva, Giada Ostinelli, Audrey Provencher-Girard, Shadai Salazar, Rana Melhem, Guy A. Rutter (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13124488.txt.
Description
A peer-reviewed research article from Europe PMC (2026). Increases in cytoplasmic free Ca2+ ions ([Ca2+]) are a critical signal in pancreatic islet beta-cells and are usually required for insulin secretion in response to glucose or other secretagogues. Changes in Ca2+, monitored using high-speed imaging across individual or multiple planes of the islet, can be used to explore the functional networks of beta-cells required for the precise regulation of insulin secretion.
Catalog record
| CREATOR | Luis Fernando Delgadillo-Silva, Giada Ostinelli, Audrey Provencher-Girard, Shadai Salazar, Rana Melhem, Guy A. Rutter |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |