Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review

Abdul Rehman, Mehsim Abid, Hira Jamil, Sadia Siddique, Sagar Parkash, FNU Nasrullah, FNU Sapna, Bhawna Lohana, Kiran Lohana, Inshal Jawed, Mohammad Tufail, Mohammad Sarim Sharaf · 2026

Read Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review by Abdul Rehman, Mehsim Abid, Hira Jamil, Sadia Siddique, Sagar Parkash, FNU Nasrullah, FNU Sapna, Bhawna Lohana, Kiran Lohana, Inshal Jawed, Mohammad Tufail, Mohammad Sarim Sharaf (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13121996.txt.

Description

Abdul Rehman leads a 2026 systematic review comparing injectable blood thinners for heparin-induced thrombocytopenia, a dangerous immune reaction to the thinner heparin that drops platelet counts and can cause clots. Heparin must stop at once, but which replacement works best was uncertain. The authors gathered studies up to January twenty twenty-five.

Sixteen studies covering nearly two thousand nine hundred patients were included, with only one randomized trial among them. Clot and major bleeding rates each fell in a similar mid range across drugs. Fondaparinux looked favorable in retrospective reports, while the other two drugs performed alike. Certainty was rated low to very low, so no drug could be ranked, and proper trials are needed.

Catalog record

CREATORAbdul Rehman, Mehsim Abid, Hira Jamil, Sadia Siddique, Sagar Parkash, FNU Nasrullah, FNU Sapna, Bhawna Lohana, Kiran Lohana, Inshal Jawed, Mohammad Tufail, Mohammad Sarim Sharaf
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE41074
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13121996

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