Effect of Acid-Stabilizing Hemagglutinin Mutations on Immunogenicity and Heterologous Protection by H1N1 Influenza Virus mRNA-LNP Vaccines
Chet R. Ojha, Samuel W. Rovito, Balaji Banoth, Hyunsuh Kim, Jeremy C. Jones, Mohamad-Gabriel Alameh, Po-Ling Chen, Richard J. Webby, Drew Weissman, Charles J. Russell · 2026
Read Effect of Acid-Stabilizing Hemagglutinin Mutations on Immunogenicity and Heterologous Protection by H1N1 Influenza Virus mRNA-LNP Vaccines by Chet R. Ojha, Samuel W. Rovito, Balaji Banoth, Hyunsuh Kim, Jeremy C. Jones, Mohamad-Gabriel Alameh, Po-Ling Chen, Richard J. Webby, Drew Weissman, Charles J. Russell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13119996.txt.
Description
While current influenza vaccines often lack broad protection against antigenically drifted strains, some modified hemagglutinin (HA) protein antigens have shown promise in eliciting broadly neutralizing antibodies against conserved epitopes. During infection, the mildly acidic environment of the late endosome triggers irreversible HA conformational changes resulting in a post-fusion structure with altered antigenicity.
Catalog record
| CREATOR | Chet R. Ojha, Samuel W. Rovito, Balaji Banoth, Hyunsuh Kim, Jeremy C. Jones, Mohamad-Gabriel Alameh, Po-Ling Chen, Richard J. Webby, Drew Weissman, Charles J. Russell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |