Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids
Im-Sook Song, Minyeong Pang, Min Seo Lee, Jihoon Lee, Kwang-Hyeon Liu, Min-Koo Choi, Han-Jin Park, Hyemin Kim, Hye Suk Lee · 2026
Read Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids by Im-Sook Song, Minyeong Pang, Min Seo Lee, Jihoon Lee, Kwang-Hyeon Liu, Min-Koo Choi, Han-Jin Park, Hyemin Kim, Hye Suk Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13119268.txt.
Description
Objectives: This study aims to identify the reactive metabolite of acetaminophen (AAP) and the cyanopyrrolidine metabolite of saxagliptin in human induced pluripotent stem cell-derived hepatic organoids (HHOs) and to compare them with human liver microsomes (HLMs) and plateable cryopreserved human hepatocytes (CHHs) to evaluate the feasibility of HHOs for reactive metabolite screening and metabolite profiling.
Catalog record
| CREATOR | Im-Sook Song, Minyeong Pang, Min Seo Lee, Jihoon Lee, Kwang-Hyeon Liu, Min-Koo Choi, Han-Jin Park, Hyemin Kim, Hye Suk Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |