High-Level Production of NMN in Escherichia coli Through Co-Utilization of Glucose and Glycerol
Jiajia Gan, Xiuzhen Chen, Yongzhi He, Yanfeng Zhang, Jin Zhong, Zhiyang Dong · 2026
Read High-Level Production of NMN in Escherichia coli Through Co-Utilization of Glucose and Glycerol by Jiajia Gan, Xiuzhen Chen, Yongzhi He, Yanfeng Zhang, Jin Zhong, Zhiyang Dong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13119108.txt.
Description
Jiajia Gan and co-authors brewed a prized supplement ingredient in bacteria in two thousand twenty-six. The compound, NMN, feeds the cell's vital NAD coenzyme supply. It is linked to healthy aging effects. Engineered Escherichia coli offered a factory route. Their strain was rebuilt to eat two sugars at once. Glucose and glycerol together fed production.
Key glucose-burning genes were deleted in sequence. That freed raw material for the target compound. A tweaked glycerol enzyme restored growth balance. Output reached high levels in the fermenter. Feedstock from waste glycerol adds green appeal. The strain turns cheap inputs into a premium product. Scale-up work can build on the blueprint.
Catalog record
| CREATOR | Jiajia Gan, Xiuzhen Chen, Yongzhi He, Yanfeng Zhang, Jin Zhong, Zhiyang Dong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |