Proteomics in Cardiovascular Deaths, a Postmortem Pilot Study: The Diagnostic Efficacy of α-1 Antitrypsin and Apolipoprotein A-IV in Ischemic and Congestive Deaths
Marina Invernón Monedero, María Esther Pérez Artiago, Juan Pedro Hernández del Rincón, María Dolores Fuentes, María D. Pérez-Cárceles, Eduardo Osuna, Diana Hernández-Romero · 2026
Read Proteomics in Cardiovascular Deaths, a Postmortem Pilot Study: The Diagnostic Efficacy of α-1 Antitrypsin and Apolipoprotein A-IV in Ischemic and Congestive Deaths by Marina Invernón Monedero, María Esther Pérez Artiago, Juan Pedro Hernández del Rincón, María Dolores Fuentes, María D. Pérez-Cárceles, Eduardo Osuna, Diana Hernández-Romero (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13114760.txt.
Description
When someone dies of heart disease, telling a blocked-artery death from a worn-out-pump death can stump even a careful autopsy. Marina Invernón Monedero and co-authors tried reading the heart's proteins instead. They profiled 572 proteins in postmortem heart tissue from ischemic, congestive, and non-cardiac deaths, then checked the best candidates in blood.
Thirty-one proteins separated the two cardiac groups. One blood protein, apolipoprotein A-IV, fully separated ischemic deaths from the non-cardiac comparison cases in their small sample. Another candidate, alpha-1 antitrypsin, did not hold up in blood. The authors warn the numbers are small and overfitting is possible. They offer protein panels as a complement to autopsy, pending larger validation.
Catalog record
| CREATOR | Marina Invernón Monedero, María Esther Pérez Artiago, Juan Pedro Hernández del Rincón, María Dolores Fuentes, María D. Pérez-Cárceles, Eduardo Osuna, Diana Hernández-Romero |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |