Neonatal Quercetin Reduces Intestinal Oxidative Damage and Upregulates Tight Junction-Related Genes in a Mouse Experimental Model of Cerebral Palsy
Isla Ariadny Amaral de Souza Gonzaga Paz, Raul Manhães-de-Castro, Glayciele Leandro de Albuquerque, Osmar Henrique dos Santos Junior, Henrique José Cavalcanti Bezerra Gouveia, Nathalia Caroline de Oliveira Melo, Francisco Carlos Amanajás de Aguiar Junior, Ana Elisa Toscano · 2026
Read Neonatal Quercetin Reduces Intestinal Oxidative Damage and Upregulates Tight Junction-Related Genes in a Mouse Experimental Model of Cerebral Palsy by Isla Ariadny Amaral de Souza Gonzaga Paz, Raul Manhães-de-Castro, Glayciele Leandro de Albuquerque, Osmar Henrique dos Santos Junior, Henrique José Cavalcanti Bezerra Gouveia, Nathalia Caroline de Oliveira Melo, Francisco Carlos Amanajás de Aguiar Junior, Ana Elisa Toscano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13113978.txt.
Description
The authors test whether a plant compound, quercetin, protects the gut in a rat model of cerebral palsy. The condition harms the brain and also the gut lining through the gut-brain axis. Young rats with the condition, and healthy ones, got quercetin or a plain vehicle in the first days of life.
The condition thinned parts of the gut and raised oxidative damage, mostly in the jejunum. Quercetin eased the oxidative stress and switched on genes that seal the gut wall in both groups. It did not fully undo the shape changes. The authors see it as a possible add-on guard for the gut.
Catalog record
| CREATOR | Isla Ariadny Amaral de Souza Gonzaga Paz, Raul Manhães-de-Castro, Glayciele Leandro de Albuquerque, Osmar Henrique dos Santos Junior, Henrique José Cavalcanti Bezerra Gouveia, Nathalia Caroline de Oliveira Melo, Francisco Carlos Amanajás de Aguiar Junior, Ana Elisa Toscano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |