Interactions between upper respiratory microbiota and psychological distress in pulmonary nodule patients: a retrospective nested case-control study based on machine learning and exploratory mediation analysis
Xin Ye, Shiyan Tan, Qiong Ma, Zifan Wang, Taoyu Wu, Zongyi Mao, Qian Wang, Chuan Zheng, Xingchen Peng, Fengming You, Yifeng Ren · 2026
Read Interactions between upper respiratory microbiota and psychological distress in pulmonary nodule patients: a retrospective nested case-control study based on machine learning and exploratory mediation analysis by Xin Ye, Shiyan Tan, Qiong Ma, Zifan Wang, Taoyu Wu, Zongyi Mao, Qian Wang, Chuan Zheng, Xingchen Peng, Fengming You, Yifeng Ren (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13105559.txt.
Description
Xin Ye and co-authors probe links between airway microbes and mental distress in lung nodule patients in a study published in 2025. People living with lung nodules often carry anxiety and low mood, yet the role of the nose and throat microbe community was unexplored. The team surveyed three hundred eighty one patients and sequenced airway samples.
About a third showed distress. Women, those with glassy nodules, and those with past nodule disease scored higher. Three bacterial groups differed between distressed and calm patients. A machine learning model mixing microbes and sex predicted distress fairly well. Further analysis hinted that two bacterial groups may sit on paths between body measures and mood scores.
Catalog record
| CREATOR | Xin Ye, Shiyan Tan, Qiong Ma, Zifan Wang, Taoyu Wu, Zongyi Mao, Qian Wang, Chuan Zheng, Xingchen Peng, Fengming You, Yifeng Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |