The pagN gene: a dual genetic determinant for biofilm formation and virulence in Salmonella Typhimurium
Asiye Nur Karaca, Nefise Akçelik, Mustafa Akçelik · 2026
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Description
Asiye Karaca and co-authors show one Salmonella gene doing double duty in the bacterium's two careers: sitting in biofilms and invading human cells. PagN was known as a surface protein that helps the germ stick and enter, but its command role was unclear. Their 2026 paper deletes the gene from Salmonella Typhimurium and watches what fails.
The mutant grew normally yet built far weaker biofilms at room temperatures, with altered colony forms, less cellulose, poor surface films, slow clumping, and cramped movement. Against human gut cells, it stuck about sixty percent less and invaded over ninety percent less; restoring the gene restored the traits. Gene-activity maps showed the loss rewiring the cell's invasion circuitry in free-swimming life and its biofilm circuitry when settled. The authors place PagN inside the global control network, not merely on the surface as a grappling hook.
Catalog record
| CREATOR | Asiye Nur Karaca, Nefise Akçelik, Mustafa Akçelik |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |