YTHDC1 recognizes METTL16-dependent m6A on caRNAs and coordinates cotranscriptional splicing
Zhong Zhang, Qi Yin, Weimin Lin, Qiwen Li, Rui Sheng, Shuang Jiang, Kexin Lei, Linfeng Liu, Lanxin Zhang, Chunlin Qian, Junru Wen, Zirui Wang, Chong Chen, Quan Yuan · 2026
Read YTHDC1 recognizes METTL16-dependent m6A on caRNAs and coordinates cotranscriptional splicing by Zhong Zhang, Qi Yin, Weimin Lin, Qiwen Li, Rui Sheng, Shuang Jiang, Kexin Lei, Linfeng Liu, Lanxin Zhang, Chunlin Qian, Junru Wen, Zirui Wang, Chong Chen, Quan Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13099616.txt.
Description
SignificanceThe presence of multiple m6A writers and readers strongly suggests undiscovered layers of functional specialization and unique modes of action, yet how these diverse components achieve precise, cell-type, or developmental stage-specific regulation remains largely unknown. We found loss of METTL3, considered to be the most dominant m6A writer, has no significant impact on limb development. Instead, METTL16 is implicated.
Catalog record
| CREATOR | Zhong Zhang, Qi Yin, Weimin Lin, Qiwen Li, Rui Sheng, Shuang Jiang, Kexin Lei, Linfeng Liu, Lanxin Zhang, Chunlin Qian, Junru Wen, Zirui Wang, Chong Chen, Quan Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |