Radionuclide-Dependent Stimulation of Antitumor Immunity in GD2-Targeted Radiopharmaceutical Therapy Combined with Immune Checkpoint Inhibitors
Cynthia Lilieholm, Jen Zaborek, Ohyun Kwon, Adedamola O Adeniyi, Caroline P Kerr, Hansel Comas Rojas, Malick Bio Idrissou, Carolina A Ferreira, Paul A Clark, Won Jong Jin, Joseph J Grudzinski, Amy K Erbe, Eduardo Aluicio-Sarduy, Thines Kanagasundaram, Justin J Wilson, Jonathan W Engle, Reinier Herna · 2025
Read Radionuclide-Dependent Stimulation of Antitumor Immunity in GD2-Targeted Radiopharmaceutical Therapy Combined with Immune Checkpoint Inhibitors by Cynthia Lilieholm, Jen Zaborek, Ohyun Kwon, Adedamola O Adeniyi, Caroline P Kerr, Hansel Comas Rojas, Malick Bio Idrissou, Carolina A Ferreira, Paul A Clark, Won Jong Jin, Joseph J Grudzinski, Amy K Erbe, Eduardo Aluicio-Sarduy, Thines Kanagasundaram, Justin J Wilson, Jonathan W Engle, Reinier Herna (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13098876.txt.
Description
Cynthia Lilieholm and a large team of co-authors test whether the choice of radioactive payload changes how well radiation therapy wakes up the immune system, in a 2025 study. The therapy targets a marker on neuroblastoma tumors and was paired with immune checkpoint drugs.
Mice with marked tumors received an antibody carrying one of three radionuclides, at two dose levels, with or without the immune drugs. All versions homed to tumors. The alpha emitter at the higher dose, plus immune drugs, gave the best survival and strong interferon-driven activation. A beta emitter instead thinned regulatory immune cells, lifting the killer-to-regulator balance. The authors conclude payload and dose must be tuned together.
Catalog record
| CREATOR | Cynthia Lilieholm, Jen Zaborek, Ohyun Kwon, Adedamola O Adeniyi, Caroline P Kerr, Hansel Comas Rojas, Malick Bio Idrissou, Carolina A Ferreira, Paul A Clark, Won Jong Jin, Joseph J Grudzinski, Amy K Erbe, Eduardo Aluicio-Sarduy, Thines Kanagasundaram, Justin J Wilson, Jonathan W Engle, Reinier Herna |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |