Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor Expression
Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafin · 2026
Read Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor Expression by Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13091597.txt.
Description
PurposeAnalyses of patients with early-stage, treatment-naïve triple-negative breast cancer (TNBC) have demonstrated that high glucocorticoid receptor (GR) expression in primary tumors is associated with poor prognosis. We previously observed that GR-high primary TNBCs exhibited significantly increased numbers of tumor-infiltrating regulatory T cells (Tregs) compared with GR-low tumors.
Catalog record
| CREATOR | Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |