Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time
Sian Sloan-Dennison, Ben Clark, Kathleen M. Scullion, Fiona Smillie, Stacey Laing, Paul Fineran, Joanne Mair, Cicely Rathmell, Dieter Bingemann, Jonathan Faircloth, David Creasey, Neil C. Shand, Chris J. Weir, James W. Dear, Duncan Graham, Karen Faulds · 2026
Read Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time by Sian Sloan-Dennison, Ben Clark, Kathleen M. Scullion, Fiona Smillie, Stacey Laing, Paul Fineran, Joanne Mair, Cicely Rathmell, Dieter Bingemann, Jonathan Faircloth, David Creasey, Neil C. Shand, Chris J. Weir, James W. Dear, Duncan Graham, Karen Faulds (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13088774.txt.
Description
Sian Sloan-Dennison is first author on a 2026 study testing the shelf life of a new kind of lateral flow test, the strip tests used at the point of care. The design adds surface enhanced Raman scattering, a laser-based signal boost, to give sensitive, countable results. Doubts about signal stability over time have held back adoption.
The test, aimed at a liver injury marker, uses silica-coated gold nanoparticles for stability in human serum. Read by a handheld device, its output was tracked for six months with several scoring methods. A slope-based normalization proved most reproducible. After five months at room temperature, signal had fallen only about eleven percent, showing the test still worked as intended.
Catalog record
| CREATOR | Sian Sloan-Dennison, Ben Clark, Kathleen M. Scullion, Fiona Smillie, Stacey Laing, Paul Fineran, Joanne Mair, Cicely Rathmell, Dieter Bingemann, Jonathan Faircloth, David Creasey, Neil C. Shand, Chris J. Weir, James W. Dear, Duncan Graham, Karen Faulds |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |