Association of multi-site microbial features with malignancy risk in pulmonary ground-glass nodules and identification of predictive biomarkers: a prospective multicenter cohort study
Chunxia Huang, Jiawei He, Xi Fu, Yang Zhong, Yuling Jiang, Aoling Yang, Hengzhou Lai, Qian Wang, Shiyan Tan, Xueke Li, Yifang Jiang, Yuli Qu, Xiang Zhuang, Ping Xiao, Yifeng Ren, Chuan Zheng, Fengming You, Qiong Ma · 2025
Read Association of multi-site microbial features with malignancy risk in pulmonary ground-glass nodules and identification of predictive biomarkers: a prospective multicenter cohort study by Chunxia Huang, Jiawei He, Xi Fu, Yang Zhong, Yuling Jiang, Aoling Yang, Hengzhou Lai, Qian Wang, Shiyan Tan, Xueke Li, Yifang Jiang, Yuli Qu, Xiang Zhuang, Ping Xiao, Yifeng Ren, Chuan Zheng, Fengming You, Qiong Ma (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13088588.txt.
Description
Chunxia Huang and a large team of co-authors published this lung study in 2025. It asks whether the microbes living in the airways can flag which hazy lung spots, called ground-glass nodules, are likely to turn out malignant. The team enrolled 748 patients at three medical centers and collected nose-and-throat swabs plus lung wash fluid. Over two years of follow-up, 251 patients proved benign and 136 malignant.
Gene sequencing mapped the microbes at each site, and seven learning methods were tried for prediction. A model built on nose-and-throat microbes performed best, since that site is also the easiest to sample. Six microbe types stood out as key markers, and adding them improved a standard clinical risk model. Further analysis tied the shift toward cancer to disturbed amino acid use and immune pathways. The authors see a swab test as a possible non-invasive aid for nodule care.
Catalog record
| CREATOR | Chunxia Huang, Jiawei He, Xi Fu, Yang Zhong, Yuling Jiang, Aoling Yang, Hengzhou Lai, Qian Wang, Shiyan Tan, Xueke Li, Yifang Jiang, Yuli Qu, Xiang Zhuang, Ping Xiao, Yifeng Ren, Chuan Zheng, Fengming You, Qiong Ma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |