Comprehensive molecular characterization of cfDNA as predictive and monitoring biomarkers in advanced gastric cancer receiving immunotherapy
Jingshuai Fang, Yuhui Yu, Yan Sun, Mengmeng Ji, Yue Jiang, Xiaofeng Chen, Caiwang Yan, Guangfu Jin · 2026
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Description
Jingshuai Fang and co-authors read tumor DNA floating in the blood of stomach cancer patients in 2026 to predict who will answer immune therapy. Advanced stomach cancer responds unevenly to these drugs, and tissue biopsies are painful and slow to repeat.
Ninety-four patients gave blood before and during treatment, split into discovery and check sets. Responders carried longer free DNA, a lower tumor share, calmer chromosomes, and slightly higher chemical tagging overall. One small tagged region on chromosome twenty stood out in both sets. A predictor built on that region beat the standard tissue score, and combining the two did better still. The authors propose blood based sorting for therapy.
Catalog record
| CREATOR | Jingshuai Fang, Yuhui Yu, Yan Sun, Mengmeng Ji, Yue Jiang, Xiaofeng Chen, Caiwang Yan, Guangfu Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |