Non-enzymatic Rnaseh2c orchestrates proliferating macrophage-driven immunosuppression and HCC progression via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8+ Tex infiltration: a novel therapeutic paradigm with “Rnaseh2c-In1” inhibitor
Zengbin Wang, Ruiying Xiao, Mengxin Liu, Lihua Ceng, Zikun Lin, Xinyu Zheng, Miaoxin Shi, Hong Ye, Linqing Wu, Nanhong Tang · 2026
Read Non-enzymatic Rnaseh2c orchestrates proliferating macrophage-driven immunosuppression and HCC progression via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8+ Tex infiltration: a novel therapeutic paradigm with “Rnaseh2c-In1” inhibitor by Zengbin Wang, Ruiying Xiao, Mengxin Liu, Lihua Ceng, Zikun Lin, Xinyu Zheng, Miaoxin Shi, Hong Ye, Linqing Wu, Nanhong Tang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13084914.txt.
Description
A peer-reviewed research article from Europe PMC (2026). BackgroundTumor-associated macrophages are pivotal drivers of hepatocellular carcinoma (HCC) progression. However, the functional contributions of proliferating macrophages (Prolif Ms) within the tumor microenvironment (TME) remain poorly defined.MethodsHere, we integrated single-cell RNA sequencing, Cleavage Under Targets and Tagmentation (CUT&Tag), bulk RNA sequencing, multiparametric immunofluorescence, flow cytometry, and molecular dynamics simulation to dissect the phenotype, functional landscape, and targeting strategy of Prolif Ms in HCC.ResultsWe identified a novel Prolif Ms subset characterized by high expression of proliferation markers (Cdk1, Mki67), distinct from classical M1/M2
Catalog record
| CREATOR | Zengbin Wang, Ruiying Xiao, Mengxin Liu, Lihua Ceng, Zikun Lin, Xinyu Zheng, Miaoxin Shi, Hong Ye, Linqing Wu, Nanhong Tang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |