Revealing erythropoietin variant EV-3 as novel driving force and immunotherapeutic target in human glioblastoma
Stefania Elena Navone, Giovanni Marfia, Laura Guarnaccia, Massimiliano Rizzaro, Giorgio Fiore, Rolando Campanella, Chiara Gaudino, Daniele Santini, Giovanni Andrea Alotta, Monica Rosa Miozzo, Emanuela Barilla, Marco Locatelli, Laura Riboni · 2025
Read Revealing erythropoietin variant EV-3 as novel driving force and immunotherapeutic target in human glioblastoma by Stefania Elena Navone, Giovanni Marfia, Laura Guarnaccia, Massimiliano Rizzaro, Giorgio Fiore, Rolando Campanella, Chiara Gaudino, Daniele Santini, Giovanni Andrea Alotta, Monica Rosa Miozzo, Emanuela Barilla, Marco Locatelli, Laura Riboni (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13067427.txt.
Description
Stefania Navone and co-authors identify a hormone variant as a driver and drug target in glioblastoma in this 2025 paper. Glioblastoma is the most aggressive primary brain tumor and stays deadly despite heavy study. Tumor cells make a hormone called erythropoietin, but the roles of its spliced variant forms in cancer were unexplored.
The team measured variant levels in human brain tumor tissue and cells and found one variant, EV-3, strongly overproduced, above all by stem-like tumor cells. They built antibodies against the variants and picked a lead one that slowed tumor growth, spread, and new vessel growth in lab tests. It showed no harm to normal brain cells and no unwanted hormone effect, and it was tested in mouse models.
Catalog record
| CREATOR | Stefania Elena Navone, Giovanni Marfia, Laura Guarnaccia, Massimiliano Rizzaro, Giorgio Fiore, Rolando Campanella, Chiara Gaudino, Daniele Santini, Giovanni Andrea Alotta, Monica Rosa Miozzo, Emanuela Barilla, Marco Locatelli, Laura Riboni |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |