Synthetic amorphous silica
Andrea Hartwig, MAK Commission · 2025
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Description
Andrea Hartwig and the MAK Commission re-evaluate the workplace exposure limit for synthetic amorphous silica. The German commission weighs all toxic effects of chemicals at work and sets a maximum air level for each. For this form of silica, the critical harm is inflammation in the lungs.
In the 2025 documentation, studies in rats found lung inflammation at the lowest test level, so no safe no-effect level could be set. From that lowest level, the commission derived a strict limit for the respirable share of the dust. Peak limits and a pregnancy risk group were also assigned, based on wide margins in the animal data. The document gathers published and unpublished study reports behind the call.
Catalog record
| CREATOR | Andrea Hartwig, MAK Commission |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |