A Pyrimidine-Based Tubulin Inhibitor Shows Potent Anti-Glioblastoma Activity In Vitro and In Vivo
Satyanarayana Pochampally, Lawrence M. Pfeffer, Gustavo A. Miranda-Carboni, Macey Daniel, Jazz I. James, Allana Smith, Chuan He Yang, Hannah R. Kelso, Deanna N. Parke, Dong-Jin Hwang, Wei Li, Duane D. Miller · 2025
Read A Pyrimidine-Based Tubulin Inhibitor Shows Potent Anti-Glioblastoma Activity In Vitro and In Vivo by Satyanarayana Pochampally, Lawrence M. Pfeffer, Gustavo A. Miranda-Carboni, Macey Daniel, Jazz I. James, Allana Smith, Chuan He Yang, Hannah R. Kelso, Deanna N. Parke, Dong-Jin Hwang, Wei Li, Duane D. Miller (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13019412.txt.
Description
Satyanarayana Pochampally and colleagues present a two thousand twenty-five study of a new tubulin-blocking compound against glioblastoma. The brain tumour resists most treatment. Tubulin, the scaffold cells use to divide, is a proven drug target in other cancers.
A focused library of pyrimidine-based compounds was made and screened on tumour cells. Several killed cells at very low doses, beating the standard drug. The best compound was tracked live as cells grew and died. In mice carrying human glioblastomas, it slowed tumour growth. The results nominate a fresh chemical family for a cancer with few options.
Catalog record
| CREATOR | Satyanarayana Pochampally, Lawrence M. Pfeffer, Gustavo A. Miranda-Carboni, Macey Daniel, Jazz I. James, Allana Smith, Chuan He Yang, Hannah R. Kelso, Deanna N. Parke, Dong-Jin Hwang, Wei Li, Duane D. Miller |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |