Impact of semaphorin, Sema3F, on the gene transcription and protein expression of CREB and its binding protein CREBBP in primary hippocampal neurons of rats
Ting Lv, Xiao-Yang Liu, Jun-Xian Fu, Zhi-Dong Qiao, Guang-Lu Yang · 2025
Read Impact of semaphorin, Sema3F, on the gene transcription and protein expression of CREB and its binding protein CREBBP in primary hippocampal neurons of rats by Ting Lv, Xiao-Yang Liu, Jun-Xian Fu, Zhi-Dong Qiao, Guang-Lu Yang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13011598.txt.
Description
Ting Lv, Xiao-Yang Liu, Jun-Xian Fu, Zhi-Dong Qiao, and Guang-Lu Yang study a guidance protein in rat brain cells in a 2025 paper. The protein is Sema3F, a signal that steers growing nerve fibers. The team tracked two gene-control proteins, CREB and CREBBP. Both may take part in axon growth and plasticity.
They grew hippocampal neurons and dosed them with Sema3F. Gene and protein levels were read at four time points. Levels dipped at five minutes, then rose to a peak at fifteen. They stayed high at thirty minutes in the tests. The fast swing hints at a role in short gene bursts. Those bursts may guide axon growth in the young brain.
Catalog record
| CREATOR | Ting Lv, Xiao-Yang Liu, Jun-Xian Fu, Zhi-Dong Qiao, Guang-Lu Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |