Roles of orexinergic and noradrenergic neuronal activity in ketamine-induced analgesia: A study using an orexin/ataxin-3 transgenic rat model
Mitsuru Tonosaki, Tetsuya Kushikata, Yoshikazu Nikaido, Daiki Takekawa, Hirotaka Kinoshita, Jyunichi Saito, Kazuyoshi Hirota · 2024
Read Roles of orexinergic and noradrenergic neuronal activity in ketamine-induced analgesia: A study using an orexin/ataxin-3 transgenic rat model by Mitsuru Tonosaki, Tetsuya Kushikata, Yoshikazu Nikaido, Daiki Takekawa, Hirotaka Kinoshita, Jyunichi Saito, Kazuyoshi Hirota (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13001767.txt.
Description
Mitsuru Tonosaki and six co-authors probe how two brain arousal systems shape ketamine's pain relief in rats, in a 2024 study. Orexin neurons drive wakefulness and talk to a noradrenaline hub in the brainstem. The team used transgenic rats whose orexin neurons are genetically degraded, plus normal rats for comparison. Pain responses were measured with hotplate and tail-flick tests after ketamine injections.
Some groups received a toxin against the noradrenaline hub, or brain injections of orexin, a receptor blocker, or both. Brain levels of orexin and noradrenaline were measured in untreated animals. If ketamine's analgesia rides on arousal circuitry, then sleep and alertness states may tune how well the drug works, a link anesthesiologists could exploit.
Catalog record
| CREATOR | Mitsuru Tonosaki, Tetsuya Kushikata, Yoshikazu Nikaido, Daiki Takekawa, Hirotaka Kinoshita, Jyunichi Saito, Kazuyoshi Hirota |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |