Radiomics in sporadic microsatellite instable, mismatch repair deficient and Lynch syndrome-associated pancreatic ductal adenocarcinoma: a pilot study
Ellis L. Eikenboom, Joséphine Magnin, Remo Alessandris, Natally Horvat, Mithat Gonen, William R. Jarnagin, Jeffrey Drebin, Michael I. D’Angelica, T. Peter Kingham, Vinod P. Balachandran, Kevin C. Soares, Anja Wagner, Manon C. W. Spaander, Jayasree Chakraborty, Alice C. Wei · 2026
Read Radiomics in sporadic microsatellite instable, mismatch repair deficient and Lynch syndrome-associated pancreatic ductal adenocarcinoma: a pilot study by Ellis L. Eikenboom, Joséphine Magnin, Remo Alessandris, Natally Horvat, Mithat Gonen, William R. Jarnagin, Jeffrey Drebin, Michael I. D’Angelica, T. Peter Kingham, Vinod P. Balachandran, Kevin C. Soares, Anja Wagner, Manon C. W. Spaander, Jayasree Chakraborty, Alice C. Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12962943.txt.
Description
Ellis Eikenboom and a large team of co-authors tested whether CT scan patterns can flag a rare pancreatic cancer subtype in a paper whose text is dated 2025. Most pancreatic cancers have a grim outlook, but tumors with broken DNA repair respond better to immune therapy. Testing for that subtype is not routine, so a scan-based clue would help.
The pilot study mined 254 measured features from scans of the pancreas and tumor in patients with and without the subtype, including Lynch syndrome cases. Random forest models built from the most telling features were checked by repeated cross-validation. The authors frame the work as a feasibility step toward non-invasive subtyping, not yet a clinical tool.
Catalog record
| CREATOR | Ellis L. Eikenboom, Joséphine Magnin, Remo Alessandris, Natally Horvat, Mithat Gonen, William R. Jarnagin, Jeffrey Drebin, Michael I. D’Angelica, T. Peter Kingham, Vinod P. Balachandran, Kevin C. Soares, Anja Wagner, Manon C. W. Spaander, Jayasree Chakraborty, Alice C. Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |