Leptin receptor gene influences pig gut microbiota both through feed intake and independently
Rafael Suárez-Mesa, Houda Laghouaouta, Jordi Estellé, Ahmad Reza Seradj, Roger Ros-Freixedes, Ramona N Pena, Joan Estany · 2025
Read Leptin receptor gene influences pig gut microbiota both through feed intake and independently by Rafael Suárez-Mesa, Houda Laghouaouta, Jordi Estellé, Ahmad Reza Seradj, Roger Ros-Freixedes, Ramona N Pena, Joan Estany (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12955066.txt.
Description
Rafael Suárez-Mesa and co-authors ask in a 2025 study whether a pig gene for appetite also reshapes the gut's microbes directly, or only by making pigs eat more. A faulty version of the leptin receptor gene makes pigs overeat and grow fat. The team compared gut and saliva microbes in pigs with two working copies against those with the faulty pair.
Stool microbes shifted with the gene while saliva microbes did not. Fourteen microbe groups tracked the gene; six were common to all pigs, rising or falling with it. Appetite explained much of the shift, but not all: the gene seems to tune the gut on its own as well.
Catalog record
| CREATOR | Rafael Suárez-Mesa, Houda Laghouaouta, Jordi Estellé, Ahmad Reza Seradj, Roger Ros-Freixedes, Ramona N Pena, Joan Estany |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |