Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia
Ekaterina Spektor, Aleksandra Mamchur, Mariia Bruttan, Liliya Artemieva, Antonina Rumyantseva, Lorena Matkava, Mikhail Ivanov, Veronika Daniel, Sergey Igorevich Mitrofanov, Irina Strazhesko, Vladimir Yudin, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Daria Kashtanova, Sergey Yudin, Veronika Skv · 2026
Read Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia by Ekaterina Spektor, Aleksandra Mamchur, Mariia Bruttan, Liliya Artemieva, Antonina Rumyantseva, Lorena Matkava, Mikhail Ivanov, Veronika Daniel, Sergey Igorevich Mitrofanov, Irina Strazhesko, Vladimir Yudin, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Daria Kashtanova, Sergey Yudin, Veronika Skv (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12950572.txt.
Description
Ekaterina Spektor and co-authors hunt for what protects the minds of long-lived adults who reach old age without dementia, in a paper published in 2025. Many such people keep sharp minds despite changes in the brain that would harm others.
The team followed 198 long-lived adults with thinking tests over two years, health checks, and a genome-wide scan. Poor mobility, hearing loss, depression, anemia, and low body weight sped decline. Lack of hobbies and high cholesterol raised the risk of sliding toward dementia. The scan found gene variants tied to resilience, including one not linked to thinking disorders before. A well-known risk gene, by contrast, showed no effect here.
Catalog record
| CREATOR | Ekaterina Spektor, Aleksandra Mamchur, Mariia Bruttan, Liliya Artemieva, Antonina Rumyantseva, Lorena Matkava, Mikhail Ivanov, Veronika Daniel, Sergey Igorevich Mitrofanov, Irina Strazhesko, Vladimir Yudin, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Daria Kashtanova, Sergey Yudin, Veronika Skv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |