Glucose-6-phosphate dehydrogenase deficiency facilitates hepatitis E virus entry and aggravates liver injury
Dongxue Chen, Xiaoxia Hu, Yuanwen Xue, Fuwen Xia, Min Li, Jiankun Liu, Fen Huang · 2025
Read Glucose-6-phosphate dehydrogenase deficiency facilitates hepatitis E virus entry and aggravates liver injury by Dongxue Chen, Xiaoxia Hu, Yuanwen Xue, Fuwen Xia, Min Li, Jiankun Liu, Fen Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12937510.txt.
Description
Dongxue Chen and six co-authors show that a common enzyme deficiency leaves people open to hepatitis E, in this 2025 study. The missing enzyme, called G6PD, normally shields red cells from oxidative damage, and its absence affects about four hundred million people. Such patients catch viruses more easily, but the hepatitis E link was uncharted.
Infection rates ran far higher in patients with the deficiency, about twenty-four percent against under one percent in a comparison group. Infected deficient patients also showed more jaundice and more pneumonia. In lab cells with the enzyme knocked down, the virus entered more easily and stress rose, while a viral protein was shown to grip the enzyme directly. The authors conclude the deficiency both invites the virus in and deepens the liver injury it causes.
Catalog record
| CREATOR | Dongxue Chen, Xiaoxia Hu, Yuanwen Xue, Fuwen Xia, Min Li, Jiankun Liu, Fen Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |