A smart amphiphilic nanoplatform amplifies ROS-mediated immunogenic cell death to suppress bladder cancer growth and metastasis
Chuntao Li, Fanhu Meng, Chunbo Lu, Aimei Li, Ziru Liu, Jin Liu, Hong Zhang, Zhengqiang Yang, Jingkun Bai · 2025
Read A smart amphiphilic nanoplatform amplifies ROS-mediated immunogenic cell death to suppress bladder cancer growth and metastasis by Chuntao Li, Fanhu Meng, Chunbo Lu, Aimei Li, Ziru Liu, Jin Liu, Hong Zhang, Zhengqiang Yang, Jingkun Bai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12924365.txt.
Description
Chuntao Li and co-authors build a tiny delivery platform that boosts immune-driven cancer cell death in bladder cancer, in a 2025 paper. Bladder cancer returns often and kills many patients. Drugs washed into the bladder are cleared fast by urine and gather poorly in tumors, and they can suppress immunity.
Their platform self-assembles into round particles that carry two agents at once. A key trait is a shape change triggered by an enzyme in the tumor setting. The particles clump into larger structures there, which should improve targeting and retention. The design uses reactive oxygen to drive a form of cell death that alerts the immune system.
Catalog record
| CREATOR | Chuntao Li, Fanhu Meng, Chunbo Lu, Aimei Li, Ziru Liu, Jin Liu, Hong Zhang, Zhengqiang Yang, Jingkun Bai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |