Endothelin-1 in the failing Fontan: pathobiology, precision therapeutics, and future trial design
Iman Maiza · 2026
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Description
Iman Maiza reviews the role of endothelin-1 in the failing Fontan circulation. The paper, reported in 2025, deals with a surgical circulation used for single-ventricle congenital heart disease, which leaves veins under high pressure and lungs without normal pulsatile flow.
Over time those trade-offs injure the lungs, liver, and lymphatic system, raising resistance and causing liver disease, protein loss, and arrhythmias. Endothelin-1 is a potent vasoconstrictor and profibrotic mediator that may unify these problems. Maiza sets out its pathobiology in lung and liver, the cohorts that show raised levels, and how precision treatments aimed at it could be tested in future trials.
Catalog record
| CREATOR | Iman Maiza |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |