Verteporfin, an inhibitor of nuclear YAP, improved multi-ciliated cell differentiation in the airway epithelium
Ryosuke Nakamura, Yo Kishimoto, Tomoko Kita, Susumu Yoshie, Shinji Kaba, Yukiko Okuno, Koichi Omori · 2025
Read Verteporfin, an inhibitor of nuclear YAP, improved multi-ciliated cell differentiation in the airway epithelium by Ryosuke Nakamura, Yo Kishimoto, Tomoko Kita, Susumu Yoshie, Shinji Kaba, Yukiko Okuno, Koichi Omori (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12903732.txt.
Description
Ryosuke Nakamura and co-authors test a drug that blocks a growth signal to restore airway sweeping cells, in work from 2025. Airways clear mucus with hair-like cells that beat in waves. Many airway diseases lose those cells, which traps mucus and feeds swelling.
A signal protein called YAP works in both the cell body and its nucleus, with mixed effects. The team checked where the protein sits in patient airway samples with varied cell counts. They then screened compounds that keep the protein out of the nucleus. One known drug fit that profile and boosted new sweeping cell growth. Keeping body-level function intact is the key twist in their approach.
Catalog record
| CREATOR | Ryosuke Nakamura, Yo Kishimoto, Tomoko Kita, Susumu Yoshie, Shinji Kaba, Yukiko Okuno, Koichi Omori |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |