Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
Xiangying Deng, Xinglong Liu, Juan Feng, Lin Zhao · 2025
Read Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma by Xiangying Deng, Xinglong Liu, Juan Feng, Lin Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12903729.txt.
Description
Xiangying Deng, Xinglong Liu, Juan Feng, and Lin Zhao show how polystyrene microplastics push a throat cancer to grow more aggressive, in a 2025 study. The particles were taken up readily by nasopharyngeal cancer cells, smaller ones most of all. Treated cells multiplied, migrated, and invaded faster, and tumors in mice grew and spread more under plastic-laced drinking water.
The mechanism runs through the cell's furnaces. Plastic exposure raised mitochondrial oxidants modestly, which switched on a defense program that blocks ferroptosis, an iron-driven cell death. Drugs that restore that death route undid the plastic's gains. The work links a common pollutant to cancer progression through a named pathway.
Catalog record
| CREATOR | Xiangying Deng, Xinglong Liu, Juan Feng, Lin Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |