CD155 reprograms glycolysis via the YAP/TEAD1-GLUT1 axis to promote lung adenocarcinoma progression and M2 macrophage polarization: a metabolic-immune target visualized by 18F-FDG PET/CT
Zhiming Cheng, Shu Wang, Shuoyan Xu, Yuxiang Wang, Yao Diao, Bulin Du, Xuena Li, Yaming Li · 2025
Read CD155 reprograms glycolysis via the YAP/TEAD1-GLUT1 axis to promote lung adenocarcinoma progression and M2 macrophage polarization: a metabolic-immune target visualized by 18F-FDG PET/CT by Zhiming Cheng, Shu Wang, Shuoyan Xu, Yuxiang Wang, Yao Diao, Bulin Du, Xuena Li, Yaming Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12903674.txt.
Description
Zhiming Cheng and seven co-authors show that an immune checkpoint protein also rewires sugar use in lung tumors. Their study was published in twenty twenty-five. The protein, CD155, was known for helping tumors evade immunity.
Eighty patients' tumors were stained and scanned with sugar-based PET imaging. High CD155 tracked with stronger glucose uptake. Lab work traced the chain: the protein switched on a growth pathway that raised a glucose transporter. It also pushed macrophages toward the tumor-friendly state. Mouse tumors confirmed the pattern in life. Blocking CD155 might thus hit fuel supply and immune cover at once, and scans can watch it happen.
Catalog record
| CREATOR | Zhiming Cheng, Shu Wang, Shuoyan Xu, Yuxiang Wang, Yao Diao, Bulin Du, Xuena Li, Yaming Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |