Dynamic screening initiation using 16 plasma protein biomarkers with polygenic risk and PLCOm2012: a precision prevention framework for lung cancer
Runchen Wang, Zhiming Ye, Qixia Wang, Rong Xu, Yi Feng, Na Zhao, Yun Yan, Yulin Zhao, Xuanzhuang Lu, Xiangyuan Zheng, Jianqi Zheng, Hongsheng Deng, Ran Zhong, Rui Gao, Jie Li, Wenhua Liang, Jianxing He, Hengrui Liang · 2025
Read Dynamic screening initiation using 16 plasma protein biomarkers with polygenic risk and PLCOm2012: a precision prevention framework for lung cancer by Runchen Wang, Zhiming Ye, Qixia Wang, Rong Xu, Yi Feng, Na Zhao, Yun Yan, Yulin Zhao, Xuanzhuang Lu, Xiangyuan Zheng, Jianqi Zheng, Hongsheng Deng, Ran Zhong, Rui Gao, Jie Li, Wenhua Liang, Jianxing He, Hengrui Liang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12903519.txt.
Description
Runchen Wang and co-authors build a sharper way to decide when each person should start screening for lung cancer. Checks now rest mostly on age and smoking past, which screens some low risk people too much and reaches some high risk people too late.
The team joined sixteen blood protein markers with a gene based risk score and a known risk model. The blend gave a joint score that predicted lung cancer well over three, five, and ten years. People at high risk crossed a set risk line more than a decade early. The work aims to set a start age that fits each person.
Catalog record
| CREATOR | Runchen Wang, Zhiming Ye, Qixia Wang, Rong Xu, Yi Feng, Na Zhao, Yun Yan, Yulin Zhao, Xuanzhuang Lu, Xiangyuan Zheng, Jianqi Zheng, Hongsheng Deng, Ran Zhong, Rui Gao, Jie Li, Wenhua Liang, Jianxing He, Hengrui Liang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |