Mechanistic study on how the Tet1/ARF-p53 pathway affects idiopathic pulmonary fibrosis through macrophage polarization
Peng Zhang, Xiaotong Guo, Ting Wang, Shaojin Wang · 2025
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Description
Peng Zhang and co-authors trace a chain from a DNA-editing enzyme to the immune stance that scars lungs in a fatal disease. Their 2025 study concerns idiopathic pulmonary fibrosis, where lung tissue stiffens for no clear cause. Macrophages, the lung's resident immune cells, can lean toward a state that feeds that scarring.
The team shows that the enzyme Tet1 edits the chemical marks on the ARF gene, raising its output and waking the guardian protein p53. That pathway holds macrophages back from the scar-feeding state, and fibrosis eases as a result. The findings come from cell cultures and animal models together. The authors name the Tet1 and ARF-p53 chain a fresh target for a disease with few options.
Catalog record
| CREATOR | Peng Zhang, Xiaotong Guo, Ting Wang, Shaojin Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |