Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury
Hao Li, Yi Yang, Meng Zhang, Eric Guo, Zeheng Li, Bo Wan, Zhigang Miao, Wei Ge, Gang Chen, Xingshun Xu · 2025
Read Targeting Cend1-Atp5f1b interaction rescues mitochondrial dysfunction and ameliorates ischemic brain injury by Hao Li, Yi Yang, Meng Zhang, Eric Guo, Zeheng Li, Bo Wan, Zhigang Miao, Wei Ge, Gang Chen, Xingshun Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12902099.txt.
Description
Hao Li and co-authors trace how a protein guards brain cell power plants during stroke, in a 2025 paper. Mitochondria fail fast when blood flow stops and returns. The protein Cend1 helps keep their energy output alive. Mice lacking Cend1 were tested in a stroke model.
Knockout mice suffered bigger dead zones and worse movement. Energy molecule levels and membrane health dropped further without the protein. Cend1 pairs up through a small motif to boost energy synthesis. Breaking that pairing destabilized the protein. Aiming drugs at this interaction may protect stroke patients brains.
Catalog record
| CREATOR | Hao Li, Yi Yang, Meng Zhang, Eric Guo, Zeheng Li, Bo Wan, Zhigang Miao, Wei Ge, Gang Chen, Xingshun Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |