Identification of Sjögren’s disease–associated T cell receptor motifs through deep sequencing
Ananth Aditya Jupudi, Michelle L Joachims, Christina Lawrence, Charmaine Lopez-Davis, Bhuwan Khatri, Astrid Rasmussen, Kiely Grundahl, R Hal Scofield, Judith A James, Joel M Guthridge, Christopher J Lessard, Linda F Thompson, A Darise Farris · 2025
Read Identification of Sjögren’s disease–associated T cell receptor motifs through deep sequencing by Ananth Aditya Jupudi, Michelle L Joachims, Christina Lawrence, Charmaine Lopez-Davis, Bhuwan Khatri, Astrid Rasmussen, Kiely Grundahl, R Hal Scofield, Judith A James, Joel M Guthridge, Christopher J Lessard, Linda F Thompson, A Darise Farris (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12890531.txt.
Description
Ananth Aditya Jupudi and co-authors used deep gene sequencing to find immune cell patterns tied to Sjögren's disease, in a study published in 2025. In this disease, immune cells gather in the saliva glands and damage them, causing dry mouth. The team focused on the receptor codes that let these cells pick their targets.
They sequenced receptors from blood cells of patients and healthy controls, plus gland cells from the same patients. Some expanded gland cells shared receptor codes with blood cells, and patient blood showed a narrower, more private set of codes than healthy blood. The shared codes grew more common as saliva flow fell. The team also found two protein targets that these cells attack, which could guide future treatments.
Catalog record
| CREATOR | Ananth Aditya Jupudi, Michelle L Joachims, Christina Lawrence, Charmaine Lopez-Davis, Bhuwan Khatri, Astrid Rasmussen, Kiely Grundahl, R Hal Scofield, Judith A James, Joel M Guthridge, Christopher J Lessard, Linda F Thompson, A Darise Farris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |